Wednesday, November 5, 2014

Adverse Effects of Statins - Myths and Reality.

BACKGROUND: Statins reduce cardiovascular mortality and morbidity as well as cardiovascular events in moderate to high risk patients. However, there are many concerns that their adverse effects might compromise their proven beneficial effects.

QUESTION: are statins more harmful than beneficial?

RESULTS: this review article concludes the following:


  • ADVERSE EFFECTS
    • myopathy
    • rhabdomyolysis
    • reversible increased activity of liver function tests
    • small increase in the incidence of type 2 diabetes mellitus
    • adverse renal effects
  • BENEFICIAL EFFECTS
    • decrease cardiovascular events
    • can improve hepatic steatosis
    • protect against renal dysfunction
    • possible beneficial effect on cancer
    • possible beneficial effect in preventing dementia

  • NET EFFECT
    • Systematic reviews and clinical guidelines suggest that the cardiovascular benefits of statins by far out-weight non-cardiovascular harms in patients with cardiovascular risk.


Curr Pharm Des. 2014 Oct 13;